Scientists have discovered a regulator of gene activity that tells epidermal stem cells when it”s time to grow more skin, as well as a “crowd control” molecule that can sense cell crowding and turn the growth off.

The findings could also aid efforts to grow skin grafts and treat burn patients.

Image: Cell Press

“We have found a molecular switch that tells your skin to keep growing or stop growing,” said Fernando Camargo at Children’s Hospital Boston.

Camargo and colleagues manipulated a molecule called Yap1 to cause massive tumor growth by triggering a pathway known as Hippo.

When they suppressed Yap1 function in mice, their epidermal skin stem cells failed to expand and they had thin, fragile skin. The opposit

Full Article